Researchers from Stanford University and the VA Palo Alto Health Care System will expand the planned clinical research studies to include measurement of changes in steroidogenesis parameters in middle-aged men before, during and after a course of Cyclic Variations in Altitude Conditioning™. Reductions of LDL (bad) cholesterol as well as increases in testosterone are key outcomes to be evaluated.

TEMECULA, Calif., April 9, 2007-- CVAC(TM) Systems, Inc. and researchers from Stanford University and the VA Palo Alto Health Care System (VAPAHCS) have entered into a new agreement to expand research to include the effect of the Cyclic Variations in Altitude Conditioning (CVAC ) process in middle-aged men. The study is currently recruiting subjects and is expected to commence the second week of April 2007. A second CVAC system will be supplied to the VAPAHCS as part of the agreement.

The principal investigator of the study is Anne L. Friedlander, PhD., Director of the Exercise Physiology Lab in the Clinical Studies Unit at the VAPAHCS and a Consulting Professor for the Program in Human Biology at Stanford University. Dr. Friedlander comments, "This 8- week protocol is designed to measure a wide variety of outcomes including cholesterol profiles and hormones, such as testosterone, to determine if the CVAC(TM) process can significantly reduce the risk factors of diseases associated with the metabolic syndrome and aging. This is an exciting area of research that, if proven to be effective, could have a profound impact on health, quality of life and longevity."

"This new area of research into the natural steroidogenic effects of the CVAC process is especially important because recent data from a study of 950 men in the "Massachusetts Male Aging Study," published in the March 2006 Journal of Clinical Endocrinology & Metabolism, links low total testosterone levels to the development of metabolic syndrome. Moreover, the "Rancho Bernardo Study" of 294 men, published in 2002 by the American Diabetes Association in Diabetes Care, links low total testosterone to the development of type 2 diabetes and insulin resistance. Also, the March 2006 issue of the Journal of the American Medical Association contains a systematic review and meta-analysis in which Harvard Medical School researchers concluded that high testosterone levels are associated with a lower risk of the development of type 2 diabetes in men," commented Allen Ruszkowski, President and CEO of CVAC Systems, Inc.

About VAPAHCS

VAPAHCS is a teaching hospital, providing a full range of patient care services, with state-of-the-art technology as well as education and research. VAPAHCS maintains one of the top three research programs in the VA. An Affiliation with the Stanford University School of Medicine provides a rich academic environment including medical training for physicians in virtually all specialties and subspecialties.

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The CVAC service is available for improved fitness only.  It is not available to diagnose or treat any disease or other medical condition.

CVAC Systems, Inc. recommends that you consult with a physician prior to beginning the CVAC process or any other exercise.  Contact a CVAC service provider for use restrictions.